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| 9. |  | LOBAK, T.; PASINI, A.; OLIVEIRA, H. C.; FRACETO, L. F.; ROGGIA, S. Atividade inseticida de nanoformulação à base de azadiractina sobre Anticarsia gemmatalis (Lepidoptera: Erebidae). In: CONGRESSO BRASILEIRO DE ENTOMOLOGIA, 27.; CONGRESSO LATINO-AMERICANO DE ENTOMOLOGIA, 10., 2018, Gramado, RS. Saúde, ambiente e agricultura: anais. Santo Antonio de Goiás: SEB: UFSM, 2018. v. 2. resumo. p. 1650.| Biblioteca(s): Embrapa Soja. |
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| 11. | | NASCIMENTO, H. M. do; MAGALHÃES, F. M. da S.; OLIVEIRA, H. C. de; VIDAL, M. C. Chácara do Sr. Heleno: uma unidade em transição agroecológica no Distrito Federal. Cadernos de Agroecologia, Porto Alegre, v. 13, n. 1, jul. 2018. 5 p. não paginado. Edição dos anais do VI Congresso Latino-Americano (CLAA), X Congresso Brasileiro (CBA), V Seminário do DF e Entorno (SEMDF). 2017. Brasília, DF.| Biblioteca(s): Embrapa Hortaliças. |
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| 15. | | FERNANDES, C. de S.; FERNANDES, F. E. P.; GARCIA, R.; OLIVEIRA, A. C.; OLIVEIRA, H. C.; CEZÁRIO, A. S. Adubação nitrogenada e posição de amostragem em sistema silvipastoril. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 47., 2010, Salvador. Empreendedorismo e progresso científico na zootecnia brasileira: anais. Salvador: SBZ, 2010. 3 f. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 17. | | ALBUQUERQUE, F. P. de; PREISLER, A. C.; FRACETO, L. F.; OLIVEIRA, H. C.; CASTRO, V. L. S. S. de. Overview of nanopesticide environmental safety aspects and regulatory issues: the case of nanoatrazine. In: FRACETO, L. F.; CASTRO, V. L. S. S. de; GRILLO, R.; ÁVILA, D.; OLIVEIRA, H. C.; LIMA, R. de (Ed.). Nanopesticides: from research and development to mechanisms of action and sustainable use in agriculture. Cham: Springer, 2020. p. 281-298.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 18. | | ALVIM, H. G. O.; LIMA, T. B. de; OLIVEIRA, H. C. B.; GOZZO, F. C.; MACEDO, J. L.; ABDELNUR, P. V.; SILVA, W. A.; NETO, B. A. D. On the Biginelli Reaction under Homogeneous Catalysis. In: Brazilian Meeting on Organic Synthesis, 15., Campos do Jordão, SP, [Anais...] São Paulo: Bucher, 2013.| Biblioteca(s): Embrapa Agroenergia. |
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| 20. | | CAMPOS, F. G.; IBELLI, A. M. G.; CANTAO, M. E.; OLIVEIRA, H. C. de; PEIXOTO, J. de O.; LEDUR, M. C.; GUIMARÃES, S. E. F. Identification of long non-coding RNAS (LNCRNAS) in swine fetus. In: BRAZILIAN CONGRESS OF GENETICS, 68., 2023, Ouro Preto. Paleogenomics: sequencing ancient DNA. E-book. Ribeirão Preto: Sociedade Brasileira de Genética, 2023. p. 319.| Biblioteca(s): Embrapa Suínos e Aves. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
10/11/2020 |
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Data da última atualização: |
10/11/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
OLIVEIRA, H. C. de; IBELLI, A. M. G.; GUIMARÃES, S. E. F.; CANTAO, M. E.; PEIXOTO, J. de O.; COUTINHO. L. L.; LEDUR, M. C. |
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Afiliação: |
HANIEL CEDRAZ DE OLIVEIRA, UFL; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; SIMONE ELIZA FACIONI GUIMARÃES, UFL; MAURICIO EGIDIO CANTAO, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; LUIZ LEHMANN COUTINHO, USP; MONICA CORREA LEDUR, CNPSA. |
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Título: |
RNA-seq reveals downregulated osteochondral genes potentially related totibia bacterial chondronecrosis with osteomyelitis in broilers. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
BMC Genetics, v. 21, n. 58, 2020. |
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DOI: |
https://doi.org/10.1186/s12863-020-00862-2 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract Background: Bacterial chondronecrosis with osteomyelitis (BCO) develops in the growth plate (GP) of the proximal femur and tibia and is initiated by damage to the less mineralized chondrocytes followed by colonization of opportunistic bacteria. This condition affects approximately 1% of all birds housed, being considered one of the major causes of lameness in fast growing broilers. Although several studies have been previously performed aiming to understand its pathogenesis, the molecular mechanisms involved with BCO remains to be elucidated. Therefore, this study aimed to generate a profile of global differential gene expression involved with BCO in the tibia of commercial broilers, through RNA sequencing analysis to identity genes and molecular pathways involved with BCO in chickens. Results: Our data showed 192 differentially expressed (DE) genes: 63 upregulated and 129 downregulated in the GP of the tibia proximal epiphysis of BCO-affected broilers. Using all DE genes, six Biological Processes (BP) were associated with bone development (connective tissue development, cartilage development, skeletal system development, organ morphogenesis, system development and skeletal system morphogenesis). The analyses of the upregulated genes did not indicate any significant BP (FDR < 0.05). However, with the downregulated genes, the same BP were identified when using all DE genes in the analysis, with a total of 26 coding genes explaining BCO in the tibia: ACAN, ALDH1A2, CDH7, CHAD, CHADL, COL11A1, COMP, CSGALNACT1, CYR61, FRZB, GAL3ST1, HAPLN1, IHH, KIF26B, LECT1, LPPR1, PDE6B, RBP4A, SERINC5, SFRP1, SOX8, SOX9, TENM2, THBS1, UCHL1 and WFIKKN2. In addition, seven transcription factors were also associated to BCO: NFATC2, MAFB, HIF1A-ARNT, EWSR1-FLI1, NFIC, TCF3 and NF-KAPPAB. Conclusions: Our data show that osteochondral downregulated genes are potential molecular causes of BCO in broilers, and the bacterial process seems to be, in fact, a secondary condition. Sixteen genes responsible for bone and cartilage formation were downregulated in BCO-affected broilers being strong candidate genes to trigger this disorder. MenosAbstract Background: Bacterial chondronecrosis with osteomyelitis (BCO) develops in the growth plate (GP) of the proximal femur and tibia and is initiated by damage to the less mineralized chondrocytes followed by colonization of opportunistic bacteria. This condition affects approximately 1% of all birds housed, being considered one of the major causes of lameness in fast growing broilers. Although several studies have been previously performed aiming to understand its pathogenesis, the molecular mechanisms involved with BCO remains to be elucidated. Therefore, this study aimed to generate a profile of global differential gene expression involved with BCO in the tibia of commercial broilers, through RNA sequencing analysis to identity genes and molecular pathways involved with BCO in chickens. Results: Our data showed 192 differentially expressed (DE) genes: 63 upregulated and 129 downregulated in the GP of the tibia proximal epiphysis of BCO-affected broilers. Using all DE genes, six Biological Processes (BP) were associated with bone development (connective tissue development, cartilage development, skeletal system development, organ morphogenesis, system development and skeletal system morphogenesis). The analyses of the upregulated genes did not indicate any significant BP (FDR < 0.05). However, with the downregulated genes, the same BP were identified when using all DE genes in the analysis, with a total of 26 coding genes explaining BCO in the tibia: ACAN, ALDH1A2, CD... Mostrar Tudo |
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Palavras-Chave: |
BCO; RNA-Seq. |
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Thesagro: |
Cartilagem; Claudicação; Frango de Corte; Genética Animal; Osteomielite. |
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Thesaurus NAL: |
Animal genetics; Broiler chickens; Cartilage; Gallus gallus; Lameness. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03176naa a2200349 a 4500
001 2126442
005 2020-11-10
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12863-020-00862-2$2DOI
100 1 $aOLIVEIRA, H. C. de
245 $aRNA-seq reveals downregulated osteochondral genes potentially related totibia bacterial chondronecrosis with osteomyelitis in broilers.$h[electronic resource]
260 $c2020
520 $aAbstract Background: Bacterial chondronecrosis with osteomyelitis (BCO) develops in the growth plate (GP) of the proximal femur and tibia and is initiated by damage to the less mineralized chondrocytes followed by colonization of opportunistic bacteria. This condition affects approximately 1% of all birds housed, being considered one of the major causes of lameness in fast growing broilers. Although several studies have been previously performed aiming to understand its pathogenesis, the molecular mechanisms involved with BCO remains to be elucidated. Therefore, this study aimed to generate a profile of global differential gene expression involved with BCO in the tibia of commercial broilers, through RNA sequencing analysis to identity genes and molecular pathways involved with BCO in chickens. Results: Our data showed 192 differentially expressed (DE) genes: 63 upregulated and 129 downregulated in the GP of the tibia proximal epiphysis of BCO-affected broilers. Using all DE genes, six Biological Processes (BP) were associated with bone development (connective tissue development, cartilage development, skeletal system development, organ morphogenesis, system development and skeletal system morphogenesis). The analyses of the upregulated genes did not indicate any significant BP (FDR < 0.05). However, with the downregulated genes, the same BP were identified when using all DE genes in the analysis, with a total of 26 coding genes explaining BCO in the tibia: ACAN, ALDH1A2, CDH7, CHAD, CHADL, COL11A1, COMP, CSGALNACT1, CYR61, FRZB, GAL3ST1, HAPLN1, IHH, KIF26B, LECT1, LPPR1, PDE6B, RBP4A, SERINC5, SFRP1, SOX8, SOX9, TENM2, THBS1, UCHL1 and WFIKKN2. In addition, seven transcription factors were also associated to BCO: NFATC2, MAFB, HIF1A-ARNT, EWSR1-FLI1, NFIC, TCF3 and NF-KAPPAB. Conclusions: Our data show that osteochondral downregulated genes are potential molecular causes of BCO in broilers, and the bacterial process seems to be, in fact, a secondary condition. Sixteen genes responsible for bone and cartilage formation were downregulated in BCO-affected broilers being strong candidate genes to trigger this disorder.
650 $aAnimal genetics
650 $aBroiler chickens
650 $aCartilage
650 $aGallus gallus
650 $aLameness
650 $aCartilagem
650 $aClaudicação
650 $aFrango de Corte
650 $aGenética Animal
650 $aOsteomielite
653 $aBCO
653 $aRNA-Seq
700 1 $aIBELLI, A. M. G.
700 1 $aGUIMARÃES, S. E. F.
700 1 $aCANTAO, M. E.
700 1 $aPEIXOTO, J. de O.
700 1 $aCOUTINHO. L. L.
700 1 $aLEDUR, M. C.
773 $tBMC Genetics$gv. 21, n. 58, 2020.
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